Sync Bio

Cell Screening for the Computational Age

We provide data collection as a service, running experiments on our in-house lab hardware and delivering you the data. Our fully-automated end-to-end culturing and screening system minimizes contamination and reduces variability.

Scale

We can run 1000+ microplates in parallel with imaging of every well multiple times per day.

Culturing

We can culture a wide range of human cell lines. Our system provides control of temperature, humidity, CO2, and oxygen. We monitor cell growth rates and can perform automatic media changes and passaging.

We support a variety of plate types, including Transwell plates, BioStellar plates, and Autoflask plates. We can produce custom plates for running complex co-cultures.

Perturbation

Our systems perform precisely-timed sub-microliter dispensing and microliter-scale pipetting. Dispensing and pipetting volumes are verified and recorded along with environmental variables.

Measurement

We can carry out a variety of fluorescence-based measurements, including proteomics, metabolomics, and ADME assays. We also offer single-cell RNA sequencing using combinatorial indexing.

Live Data Access

All data from the experiments is fed into our servers, providing easy and immediate access (through web interfaces, APIs, and Python libraries). You can check experiment progress, download data, and start analysis while the experiments are still in progress.

Pricing

We offer a lower cost-per-cell than any other CRO by using fully-automated custom-built hardware for all culturing, perturbation, and imaging. Our optimized protocols let us offer scRNA-seq for under $0.05 per cell (including barcoding and sequencing).

Modularity

Our core technology is a compact lab-in-a-box device. Each box provides incubation, plate handling (for up to 100 plates), imaging, and dispensing. Some boxes are configured with pipettors, centrifuges, and PCR hardware.

The boxes are mounted on racks with built-in mechanisms for transferring plates between devices, allowing 20+ boxes to operate in one room.

Learn More

Reach out to cells@sync.bio for more information.